What is a Trifluoroacetic acid (CF₃COOH)?

Trifluoroacetic acid (CF₃COOH) is a colorless liquid that is a derivative of acetic acid with a trifluoromethyl group (CF₃). It is a strong acid with high reactivity and is commonly used in chemical synthesis, biochemical experiments, and analytical applications. Trifluoroacetic acid acts as a strong proton donor, making it useful in peptide synthesis, pharmaceutical manufacturing, and organic reactions as a catalyst. It is also used as a solvent for peptides and proteins. Due to its high acidity, it requires careful handling to avoid skin and respiratory irritation, with appropriate protective measures and ventilation.

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