What is a Automatic synthesizer?

The automated synthesizer was developed for the purpose of automating various organic syntheses that were traditionally done manually. It is a device that greatly contributes to labor saving and efficiency improvement in the field of research and development. There are various types including those under development, but the main ones already on the market are ordinary liquid phase organic synthesizers, microwave peptide solid phase synthesizers, flow synthesizers, etc. Although it is not as popular as the analyzer at the laboratory level, active development of the device is underway.

Application of Automatic synthesizer

It has a wide range of applications, from organic compound synthesis and peptide synthesis at the laboratory level to parallel synthesis in drug discovery screening and process development. There are various sizes, from small products for small-scale studies to large pilot plant-class products for scale-up studies in process development. In the laboratory, it is used for the development of new reactions and the study of optimization of synthetic reaction pathways. By automating this device, reproducibility is improved, more accurate reaction condition control is performed, and dangerous substances of the experimenter are used. You can reduce the amount of exposure to. In addition, since experimental data is automatically recorded in a computer, more accurate experimental records can be obtained efficiently, and accurate temperature monitoring can suppress thermal runaway such as when reagents are added. In drug discovery screening, it is possible to prepare a large number of lead compounds more efficiently, so rapid and wide-ranging screening will lead to the discovery of efficient drug discovery seeds. In the development of chemical processes, it is necessary to solve many problems in terms of synthesis efficiency, safety, cost, etc. when scaling up laboratory-level synthesis to the plant scale. Heat transfer and heat removal are particularly important points, but efficiency can be improved by conducting studies while monitoring the reaction calorific value with an automated synthesizer. In addition, by automating the concentration, addition rate, stirring, etc. by machine, in situ monitoring can be facilitated, reproducibility can be improved, and efficient condition optimization can be performed.

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